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《医学前沿(英文)》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词: stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
《医学前沿(英文)》 doi: 10.1007/s11684-023-1037-3
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 404-415 doi: 10.1007/s11684-021-0834-9
关键词: Zika virus clinical drugs ZIKV inhibitors antivirals repurposing
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 430-436 doi: 10.1007/s11684-016-0492-5
Acquired thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathy. This study aimed to provide a profile of the diagnosis and management of patients with acquired TTP collected in 10 years in a single center in southeast China. A total of 60 patients diagnosed with acute acquired TTP from March 2005 to August 2015 were enrolled. Among the 60 patients, 52 patients presented with their first episodes, and eight patients had two or more episodes. The median age at presentation was 49 (range, 17 to 78) years with a female predominance (male:female ratio, 1:1.60). ADAMTS 13 activity were analyzed in 43 patients, among whom 33 (76.7%) patients had a baseline level of<5%. Mortality was 30%. Plasma exchange (PEX) was performed in 62 of 69 (89.9%) episodes. Corticosteroids were administered in 54 of 69 (78.3%) episodes. Other immunosuppressants (e.g., vincristine, cyclosporine, and cyclosporin) were used in 7 of 69 (10.1%) episodes. Rituximab was documented in 4 patients with refractory/relapsed TTP for 5 episodes, showing encouraging results. In conclusion, the diagnosis of TTP depended on a comprehensive analysis of clinical data. Plasma ADAMTS13 activity assay helped confirm a diagnosis. PEX was the mainstay of the therapy, and rituximab can be used in relapsed/refractory disease.
关键词: thrombotic thrombocytopenic purpura ADAMTS 13 plasma exchange
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
《环境科学与工程前沿(英文)》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1140-5
We developed a method for determining 11 abused drugs in water and sediment. METH and EPH were the dominant drugs in water and sediment in Beiyunhe River. Abuse drugs in Beiyunhe River were mainly from hospitals and sewage effluents. Abused drugs in the water would not impair the aquatic ecosystem biologically.
关键词: Drugs of abuse Occurrence Distribution Urban river Environmental risk
《农业科学与工程前沿(英文)》 2023年 第10卷 第2期 页码 306-332 doi: 10.15302/J-FASE-2023488
● Using visual analysis to predict the trend of natural product pest resistance.
关键词: anti-pest activity crop protection insect pest natural product visual analysis
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
《医学前沿(英文)》 2022年 第16卷 第5期 页码 815-826 doi: 10.1007/s11684-021-0891-0
关键词: B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic
《医学前沿(英文)》 2023年 第17卷 第4期 页码 729-746 doi: 10.1007/s11684-022-0978-2
关键词: hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词: nanocarrier cellular uptake endosomal release nucleic acid drug
A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0722-2
关键词: modular robotic arm anti-parallelogram mechanism Bowden cable humanoid arm lightweight joint design
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1866-1878 doi: 10.1007/s11705-023-2340-x
关键词: implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 966-975 doi: 10.1007/s11705-022-2244-1
关键词: alkali lignin red light carbon dots hypochlorite encryption and anti-counterfeiting
SUN Mingxiao, WANG Yao, CHI Jiamin
《医学前沿(英文)》 2008年 第2卷 第2期 页码 174-177 doi: 10.1007/s11684-008-0032-z
标题 作者 时间 类型 操作
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
期刊论文
Diagnosis and management of acquired thrombotic thrombocytopenic purpura in southeast China: a single
null
期刊论文
Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
期刊论文
QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE
期刊论文
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
期刊论文
Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD
期刊论文
nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs
Vaibhav Mundra, Ram I. Mahato
期刊论文
钟武:小分子抗新冠病毒药物的研究(2021年7月23日)
2021年10月23日
会议视频
Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting
期刊论文